Pneumococcal 23B Molecular Subtype Identified Using Whole Genome Sequencing
نویسندگان
چکیده
منابع مشابه
Pneumococcal 23B Molecular Subtype Identified Using Whole Genome Sequencing
The polysaccharide capsule is a major virulence factor of Streptococcus pneumoniae and the target of all currently licensed pneumococcal vaccines. At present, there are 92 serologically distinct pneumococcal serotypes. Structural and antigenic variation of capsular types is the result of genetic variation within the capsular polysaccharide synthesis (CPS) locus; however, genetic variation may n...
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Since implementation of the 13-valent polyvalent conjugate vaccine (PCV13) in Canada during 2010, the proportion of PCV13 serotypes causing invasive pneumococcal disease (IPD) has declined from 55% (n = 1492) in 2010 to 31% (n = 764) in 2014. A concurrent increase of non-PCV13 serotypes has occurred and 22F has become the most prevalent serotype in Canada increasing from 7% (n = 183) to 11% (n ...
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2017
ISSN: 1759-6653
DOI: 10.1093/gbe/evx092